A quantity of yarn, thread, or the like, put up together, after it is taken from the reel. A skein of cotton yarn is formed by eighty turns of the thread around a fifty-four inch reel.
1923, Arthur Conan Doyle, The Adventure of the Creeping Man:
The practical application of what I have said is very close to the problem which I am investigating. It is a tangled skein, you understand. and I am looking for a loose end.