In a material manner; with regard to physical things or characteristics.
1894, United States. Congress. Senate. Committee on Finance, Opinions of Collectors of Customs Concerning Ad Valorem and Specific Rates of Duty on Imports
Tobacco, for instance, shrinks materially by frequent reshippings, and as all goods are warehoused as a convenience to importers, duties should be paid on what the importer receives.
To a significant degree.
1839, Robley Dunglison, Dunglisons American medical library''
In cases of extreme thickening of the coats of the stomach, of a scirrhoid character, where the suffering patients are almost worn out with constant pain, such remedies, applied over the epigastrium, most materially alleviate the distress.